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If you’re craving a comforting dish with a spicy kick and cheesy goodness, you’re in for a real treat with this Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe. It’s a flavor-packed, hearty casserole that brings the warmth of the South straight to your table in just under an hour!

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Why You’ll Love This Recipe

  • Perfect Balance of Heat and Creaminess: The cayenne and paprika add just the right amount of southern spicy warmth to melt perfectly with creamy cheese and chicken.
  • Easy One-Dish Meal: It combines protein, carbs, veggies, and cheese—all baked in one dish, making dinner cleanup a breeze.
  • Crowd-Pleaser: Whether it’s family dinner or a potluck, this casserole hits all the right notes for a satisfying and delicious meal.
  • Customizable and Versatile: You can tweak the spice level or swap ingredients without losing any of that classic Southern charm.
A close-up view of a creamy layered pasta dish with around four layers of thick noodles, each coated in a rich, smooth orange-yellow cheese sauce. Small bits of browned bacon and herbs are scattered on top, adding texture and color with reddish-brown and green specks. The edges show melted cheese stretching and dripping slightly over the sides. The dish sits on a clean white plate with a shiny surface, and the background features a white marbled texture. Photo taken with an iphone --ar 4:5 --v 6.1

Ingredients You’ll Need

Gathering a handful of simple ingredients is all you need to create this fabulous casserole. Each one plays an essential role: the chicken provides tender protein, spaghetti adds comforting texture, the bell peppers bring a fresh crunch, and the sharp cheddar melts into cheesy magic with a spicy Southern twist.

  • Boneless, skinless chicken breasts: Choose fresh chicken for juicy, tender bites that soak up those spices beautifully.
  • Spaghetti: Cook to al dente for perfect texture—soft but with a little bite to hold up in the casserole.
  • Sharp cheddar cheese: This is the heart of the casserole’s flavor; opt for freshly shredded for ideal melting.
  • Fresh bell peppers: They add pops of color and a subtle sweetness that balances the spice.
  • Cream of chicken soup: This creamy base keeps everything luscious and binding the casserole together.
  • Paprika and cayenne pepper: For that signature fiery Southern heat that wakes up your taste buds.
  • Garlic powder: A savory layer that complements the spices beautifully.
  • Green onions: For that fresh finish and a mild onion kick as garnish.
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Note: You’ll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Variations

One of the best things about this Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe is how easy it is to make it your own. Whether you’re cooking for dietary needs or simply feel like mixing things up, these tweaks keep the dish exciting and personal.

  • Swap the Chicken for Turkey or Tofu: For a leaner option or vegetarian take, try ground turkey or firm tofu seasoned similarly and cooked before mixing in.
  • Add More Veggies: Toss in sautéed mushrooms, spinach, or corn for extra flavor and nutrition without overpowering the base.
  • Adjust the Heat Level: Increase cayenne if you like fiery dishes, or tone it down with milder paprika for a subtler spice.
  • Use Different Cheeses: Mix in pepper jack, mozzarella, or smoked gouda for a twist on the cheesy profile.

How to Make Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

Step 1: Cook the Chicken Perfectly

Start by heating a large pot over medium heat and cooking the chicken breasts for about 6 to 7 minutes per side until they’re beautifully golden and cooked through. This step creates a juicy, flavorful base. Once done, shred or chop the chicken into bite-sized pieces so it mixes well in the casserole later.

Step 2: Boil Spaghetti to Al Dente

While the chicken is cooking, bring a pot of salted water to a boil and cook your spaghetti until just al dente—usually around 8-10 minutes. Make sure it still has a slight bite because it’ll continue cooking when baked. Drain the pasta and set it aside, ready for the gooey, cheesy mix.

Step 3: Mix All Ingredients Together

In a large mixing bowl, combine the shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half of your shredded cheddar cheese. Stir everything together until evenly coated, ensuring every bite will be bursting with flavor.

Step 4: Assemble and Bake

Grease a large casserole dish and spread the mixture evenly inside. Then, sprinkle the remaining cheddar cheese on top for that irresistible golden crust. Bake in your preheated 350°F (175°C) oven for 25 to 30 minutes until the casserole is bubbly and the cheese is beautifully browned on top.

Step 5: Rest and Garnish

Let your casserole rest for about 5 minutes after baking — this helps it set perfectly. Just before serving, scatter sliced green onions on top for a fresh, mild bite and a lovely splash of color. Now it’s ready to wow everyone at the table!

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Pro Tips for Making Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

  • Don’t Overcook Chicken: Cook just until done to keep it juicy and tender rather than dry and tough.
  • Use Freshly Shredded Cheese: It melts more evenly and creates a better texture than pre-shredded options.
  • Add Spice Gradually: Start mild, then increase cayenne to match your heat tolerance—southern spice can sneak up on you!
  • Rest Before Serving: Giving the casserole time to settle after baking prevents it from being too runny, ensuring it holds together nicely on your plate.

How to Serve Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

A thick, layered pasta dish is shown close up on a white plate with a white marbled surface underneath. The dish has at least three visible layers of soft spaghetti noodles, all covered in a rich, creamy orange cheese sauce. The top layer is covered with small crispy bits of browned bacon and finely chopped green herbs, adding a mix of deep red and green colors that contrast with the smooth, shiny cheese. The edges of the dish show melted cheese stretching slightly over the side, giving a warm and inviting look. Photo taken with an iphone --ar 4:5 --v 6.1

Garnishes

The simple addition of sliced green onions or fresh parsley on top adds a burst of color and a fresh pop to cut through the richness of the cheese and spice. For a little extra zing, serve with a side of pickled jalapeños or a squeeze of fresh lime.

Side Dishes

This casserole pairs beautifully with crisp, cooling sides like a classic Southern coleslaw or a fresh garden salad. Cornbread or roasted green beans can add complementary textures and keep your plate lively without overshadowing the main dish.

Creative Ways to Present

For a fun twist, serve portions in individual ramekins or mini cast-iron skillets to impress guests. You can also dollop a spoonful of sour cream or creamy ranch on top for extra decadence. Drizzle a little hot sauce for those who love an extra kick and garnish with crispy bacon bits for indulgent crunch.

Make Ahead and Storage

Storing Leftovers

Leftovers keep wonderfully in an airtight container in the fridge for up to 3 days. The flavors actually meld even more after resting overnight, making for a delicious next-day meal.

Freezing

You can freeze the casserole either before or after baking. Wrap tightly with plastic wrap and foil or use a freezer-safe container, freezing for up to 3 months. Thaw overnight in the fridge before reheating for the best texture.

Reheating

Reheat individual portions in the microwave or warm the whole casserole in a preheated 350°F oven covered with foil to prevent drying out. Heating gently preserves the cheesy, creamy consistency you love.

FAQs

  1. Can I use rotisserie chicken for this casserole?

    Absolutely! Using rotisserie chicken saves time and adds deliciously seasoned meat to the casserole. Just shred it and proceed with the recipe as usual.

  2. How spicy is the Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe?

    The heat level is moderate thanks to the cayenne and paprika, but you can easily adjust it by adding more or less cayenne pepper based on your spice preference.

  3. Can I make this casserole gluten-free?

    Yes! Swap out regular spaghetti for your favorite gluten-free pasta, and make sure to use a gluten-free cream of chicken soup to keep it safe for gluten-sensitive diets.

  4. What can I serve with this casserole for a complete meal?

    Pair it with a crisp salad, steamed veggies, or some fresh cornbread to round out the meal with textures and flavors that complement the rich, cheesy casserole.

Final Thoughts

This Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe is a guaranteed crowd-pleaser that combines comfort and bold Southern flavor in one easy, cheesy dish. Whether you’re feeding family or friends, it’s sure to become a new favorite to make again and again. So grab your ingredients, turn up the heat, and enjoy every delicious bite of this hearty casserole!

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Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

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5 from 51 reviews

This Spicy Southern Cheesy Chicken Spaghetti Casserole is a comforting and flavorful dish combining tender chicken breasts, al dente spaghetti, and a creamy, spicy cheese sauce. Infused with bell peppers, paprika, cayenne, and garlic, it’s baked to bubbly perfection with a golden cheddar cheese crust, making it a perfect family dinner that serves eight.

  • Author: Lena
  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Total Time: 45 minutes
  • Yield: Serves 8
  • Category: Casserole
  • Method: Baking
  • Cuisine: Southern American

Ingredients

Units Scale

Chicken

  • 3-4 boneless, skinless chicken breasts (about 1.5 lbs)

Pasta

  • 8 oz spaghetti

Cheese and Dairy

  • 2 cups shredded sharp cheddar cheese
  • 1 can (10.5 oz) cream of chicken soup

Vegetables and Herbs

  • 1 cup fresh bell peppers, chopped
  • 1/4 cup green onions, sliced

Spices

  • 1 tsp paprika
  • 1/2 tsp cayenne pepper
  • 1 tsp garlic powder

Instructions

  1. Preheat Oven: Preheat your oven to 350°F (175°C) and grease a large casserole dish to prevent sticking and ensure easy serving.
  2. Cook Chicken: In a large pot over medium heat, cook the chicken breasts for about 6-7 minutes per side until they are golden brown and cooked through. Remove from heat and shred or chop the chicken into bite-sized pieces.
  3. Cook Spaghetti: Bring a large pot of salted water to a boil. Add the spaghetti and cook until al dente, about 8-10 minutes. Drain well and set aside.
  4. Mix Ingredients: In a large bowl, combine the shredded chicken, cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half of the shredded cheddar cheese. Mix everything thoroughly to ensure even distribution of flavors.
  5. Assemble Casserole: Transfer the mixture to the prepared casserole dish. Evenly sprinkle the remaining cheddar cheese on top to create a cheesy crust during baking.
  6. Bake: Place the casserole dish in the preheated oven and bake for 25-30 minutes, until the cheese is bubbly and golden brown.
  7. Rest and Garnish: Remove the casserole from the oven and let it rest for 5 minutes. Garnish with sliced green onions before serving for added color and freshness.

Notes

  • You can use rotisserie chicken to save time on cooking and shredding chicken.
  • Adjust cayenne pepper to your preferred spice level; reduce if you prefer a milder casserole.
  • Bell peppers can be substituted with diced poblano or jalapeños for extra heat.
  • Leftovers can be refrigerated for up to 3 days and reheated in the oven or microwave.
  • For a gluten-free version, substitute regular spaghetti with gluten-free pasta.
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Hi, I’m Lena Hart. I share simple, delicious recipes made for real life, from quick weeknight dinners to sweet treats you’ll want to make again and again. Let’s make your kitchen the coziest place in your home.

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